緣起：

本校積極參與永續議題國際研討會並參與跨國研究合作，與各單位共議實現永續實踐方案。

輔仁大學國際永續研究計畫

• 緣起：
  本校透過復校三單位-耶穌會、聖言會、中國聖職會與國際天主教教會網絡串聯，並發揮本校在醫療健康以及社會人文領域的優勢，透過各項獎勵機制資助研究，讓本校的研究致力於實現聯合國永續發展目標 (SDGs)，以及如何最小化權衡和創造最大化的協同效應。

2022年代表性跨國永續領域數據收集研究計畫

• 發表教師：
  醫學系 游山林助理教授兼數據科學中心主任
  
• 摘要：
  Background The association between body mass index (BMI) and oesophageal cancer (OC) has been consistently negative among Asians, whereas different associations based on histological OC subtypes have been observed in Europeans and North Americans. We examined the association between BMI and OC mortality in the Asia Cohort Consortium. Methods We performed a pooled analysis to evaluate the association between BMI and OC mortality among 842 630 Asians from 18 cohort studies. Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results A wide J-shaped association between BMI and overall OC mortality was observed. The OC mortality risk was increased for underweight (BMI <18.5 kg/m(2): HR = 2.20, 95% CI 1.80-2.70) and extreme obesity (BMI >= 35 kg/m(2): HR = 4.38, 95% CI 2.25-8.52) relative to the reference BMI (23-25 kg/m(2)). This association pattern was confirmed by several alternative analyses based on OC incidence and meta-analysis. A similar wide J-shaped association was observed in oesophageal squamous cell carcinoma (OSCC). Smoking and alcohol synergistically increased the OC mortality risk in underweight participants (HR = 6.96, 95% CI 4.54-10.67) relative to that in reference BMI participants not exposed to smoking and alcohol. Conclusion Extreme obesity and being underweight were associated with an OC mortality risk among Asians. OC mortality and BMI formed a wide J-shaped association mirrored by OSCC mortality. Although the effect of BMI on OSCC and oesophageal adenocarcinoma mortality can be different in Asians, further research based on a large case-control study is recommended.
  
• 本研究公開資料請參照：
  Web of Science

• 發表教師：
  老人長期照護學程 楊淑瑜 助理教授
  
• 摘要：
  The symptom heterogeneity of schizophrenia is consistent with Wittgenstein's analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia. Furthermore, all the BPRS items were considered to be an ordered categorical variable ranging in value from 1-7. Motor retardation was situated most centrally within the BPRS network structure, followed by depressive mood and unusual thought content. Contrastingly, hallucinatory behavior was situated least centrally within the network structure. Using a community detection algorithm, the BPRS items were organized into positive, negative, and general symptom clusters. Overall, DSM symptoms were not more central than non-DSM symptoms within the symptom network of Asian patients with schizophrenia. Thus, motor retardation, which results from the unmet needs associated with current antipsychotic medications for schizophrenia, may be a tailored treatment target for Asian patients with schizophrenia. Based on these findings, targeting non-dopamine systems (glutamate, gamma-aminobutyric acid) may represent an effective strategy with respect to precision medicine for psychosis.
  
• 本研究公開資料請參照：
  Web of Science